They then work to quickly translate those findings into treatment and prevention strategies.
Over the years of its history, the Cancer Center has made many important scientific advances including the development of a major classification scheme for lymphoma (Lukes), the discovery of the jun oncogene (Vogt), the elucidation of links between steroid hormones and breast and prostate cancer (Henderson, Ross, Pike, Bernstein, et al), the development of surgical techniques for orthotopic bladder reconstruction (Skinner), the establishment of the relationships between DNA methylation and cancer (Jones and Laird), the roles of glucose regulated proteins in cancer (Lee), the development of molecular markers for neuroblastoma (Seeger), bladder cancer (Cote), GI cancers (Lenz), 8q24’s link to prostate and colon cancer (Haiman, Henderson), and the identification of a key genetic mutation in lymphoma development (Lieber).
In MPE, investigators dissect interrelationships between exposures (e.g., environmental, dietary, lifestyle and genetic factors); alterations in cellular or extracellular molecules (disease molecular signatures); and disease evolution and progression.
Investigators can analyze genome, methylome, epigenome, metabolome, transcriptome, proteome, microbiome, immunity and interactome.
Familial linkage analyses have yielded disparate results; the use of exome sequencing in coding regions may identify novel segregating variants.Pathology and epidemiology share the same goal of elucidating etiology of disease, and MPE aims to achieve this goal at molecular, individual and population levels.Typically, MPE utilizes tissue pathology resources and data within existing epidemiology studies.Exome sequencing of familial CRC cases can identify novel rare variants that may influence disease risk.Departments of Health Sciences Research, Biomedical Statistics and Informatics, Laboratory Medicine and Pathology, Medical Genetics, Medical Genomics Technology and Advanced Genomics Technology Center, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA Colorectal cancer (CRC) in densely affected families without Lynch Syndrome may be due to mutations in undiscovered genetic loci.We completed exome sequencing on 40 affected cases from 16 multicase pedigrees to identify novel loci.